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Experiments

Compound Investigated event Experiment type Concentration Cell line Organism Animal model Stat protein Details
Tofacitinib (CP-690.550) Influence on protein activity in presence of TGF-β and IL-6 Western Blot 10.00 nM Naïve CD4+ T Mus musculus c57BL/6 p-STAT1
Tofacitinib (CP-690.550) Influence on protein activity in presence of TGF-β and IL-6 Western Blot 30.00 nM Naïve CD4+ T Mus musculus c57BL/6 p-STAT1
Tofacitinib (CP-690.550) Influence on protein activity in presence of TGF-β and IL-6 Western Blot 100.00 nM Naïve CD4+ T Mus musculus c57BL/6 p-STAT1
Tofacitinib (CP-690.550) Influence on protein activity in presence of IFNγ Western Blot 0.30 nM Naïve CD4+ T Mus musculus c57BL/6 p-STAT1
Tofacitinib (CP-690.550) Influence on protein activity in presence of IFNγ Western Blot 3.00 nM Naïve CD4+ T Mus musculus c57BL/6 p-STAT1
Tofacitinib (CP-690.550) Influence on protein activity in presence of IFNγ Western Blot 30.00 nM Naïve CD4+ T Mus musculus c57BL/6 p-STAT1
Tofacitinib (CP-690.550) Influence on protein acticity in presence of IL-6 Western Blot 30.00 nM FLS Homo sapiens p-STAT1
Tofacitinib (CP-690.550) Influence on protein acticity in presence of IL-6 Western Blot 100.00 nM FLS Homo sapiens p-STAT1
Tofacitinib (CP-690.550) Influence on protein acticity in presence of IL-6 Western Blot 300.00 nM FLS Homo sapiens p-STAT1
Tofacitinib (CP-690.550) Influence on protein acticity in presence of IL-6 Western Blot 1000.00 nM FLS Homo sapiens p-STAT1
Tofacitinib (CP-690.550) Influence on protein acticity in presence of TNF Western Blot 1000.00 nM FLS Homo sapiens p-STAT1
Tofacitinib (CP-690.550) Influence on protein activity in presence of TGF-β and IL-6 Western Blot 10.00 nM Naïve CD4+ T Mus musculus c57BL/6 STAT1
Tofacitinib (CP-690.550) Influence on protein activity in presence of TGF-β and IL-6 Western Blot 30.00 nM Naïve CD4+ T Mus musculus c57BL/6 STAT1
Tofacitinib (CP-690.550) Influence on protein activity in presence of TGF-β and IL-6 Western Blot 100.00 nM Naïve CD4+ T Mus musculus c57BL/6 STAT1
Tofacitinib (CP-690.550) Influence on protein activity in presence of IFNγ Western Blot 0.30 nM Naïve CD4+ T Mus musculus c57BL/6 STAT1
Tofacitinib (CP-690.550) Influence on protein activity in presence of IFNγ Western Blot 3.00 nM Naïve CD4+ T Mus musculus c57BL/6 STAT1
Tofacitinib (CP-690.550) Influence on protein activity in presence of IFNγ Western Blot 30.00 nM Naïve CD4+ T Mus musculus c57BL/6 STAT1
Tofacitinib (CP-690.550) Influence on protein acticity in presence of IL-6 Western Blot 30.00 nM FLS Homo sapiens STAT1
Tofacitinib (CP-690.550) Influence on protein acticity in presence of IL-6 Western Blot 100.00 nM FLS Homo sapiens STAT1
Tofacitinib (CP-690.550) Influence on protein acticity in presence of IL-6 Western Blot 300.00 nM FLS Homo sapiens STAT1
Tofacitinib (CP-690.550) Influence on protein acticity in presence of IL-6 Western Blot 1000.00 nM FLS Homo sapiens STAT1
Tofacitinib (CP-690.550) Influence on protein acticity in presence of TNF Western Blot 1000.00 nM FLS Homo sapiens STAT1